Plant-Based Pharmaceutical Coating
Official patent title
Organic nanocomposite coating for pharmaceutical applications and a method of fabrication thereof
Arabic title: طلاء نانو مركب عضوي للتطبيقات الصيدلانية وطريقة تصنيعه
Invention
Invention
Problem
Pharmaceutical coatings must form uniform films, protect the dosage form, remain stable, and deliver predictable dissolution or release. Natural-source polymers and pigments add variability and impurity-control challenges.
Why it matters
A validated plant-based coating could diversify excipient sources and create value from avocado seed and pumpkin peel while supporting capsule or tablet protection.
Approach
The coating combines nanoscale starches from avocado seed, pumpkin peel, moringa, corn, and potato with plant gels and gums, olive extract, fish-derived glycerin, pigments, and a selected plasticizer.
Who may benefit
Potential beneficiaries include pharmaceutical excipient companies, capsule manufacturers, drug-delivery laboratories, nutraceutical producers, and agricultural by-product valorization programs.
Potential value
The disclosure combines 16 nm-or-smaller plant nanostarch, natural film-forming ingredients, pigments, and plasticization in a coating that can be shaped into a 1–20 µm capsule wall.
Background
Background
Oral dosage-form coatings can protect active ingredients, mask taste, improve handling, and control where or how quickly a product dissolves. Pharmaceutical use requires consistent film strength, permeability, moisture protection, dissolution, extractables, microbial quality, and compatibility with the drug. Plant starches and gums are renewable film formers, but their composition varies with source and processing. The disclosed coating also permits several phthalate-type plasticizers, so migration, toxicology, and jurisdiction-specific excipient acceptance require careful evaluation.
Technology overview
Technology overview
Acid hydrolysis converts avocado seed, pumpkin peel, and potato starch into a plant nanostarch, which is blended with moringa and corn starch, Acacia and Lannea gums, olive-leaf extract, fish glycerin, okra gel, pigments, and plasticizer. The nanostarch is claimed at 16 nm or less and 40–60 wt.% of the coating, with pH 6.5–7.5. The mixture can be shaped as a film or capsule, dried at 25–40 °C for 1–3 hours, and formed at 1–20 µm wall thickness.
Potential applications
Potential applications
- Pharmaceutical tablet and capsule coatings.
- Nutraceutical film and capsule development.
- Taste-masking and moisture-barrier research.
- Plant-based excipient studies.
Evidence-supported advantages
Evidence-supported advantages
- Uses multiple plant-derived feedstocks.
- Produces a nanoscale starch fraction.
- Can form films or thin capsule walls.
- Includes pigments with claimed antioxidant content.
- Provides defined pH, loading, and drying ranges.
Development stage
Development stage
A composition, acid-hydrolysis process, and film or capsule-forming method are described; pharmaceutical mechanical, barrier, dissolution, migration, toxicology, stability, GMP, and regulatory performance were not established. The development stage was not independently verified.
Commercial opportunity
Commercial opportunity
The coating is an early excipient concept. Advancement requires fixed composition, film strength and elongation, moisture and oxygen permeability, disintegration and dissolution profiles with representative drugs, migration and extractables, residual acid and solvent, plasticizer toxicology, microbial limits, stability, source consistency, GMP-scale manufacture, pharmacopeial testing, and regulatory acceptance of every ingredient.
Patent classifications
Patent classifications
WIPO IPC
- A61K9/51Preparations for medical, dental or toiletry purposes
CPC
- A61K9/4816Preparations for medical, dental or toiletry purposes
- A61K9/5161Preparations for medical, dental or toiletry purposes
- A61K9/5123Preparations for medical, dental or toiletry purposes
- A61K9/286Preparations for medical, dental or toiletry purposes
Inventors
Inventors
- First inventorABM Sharif Hossain
- InventorFazliny Abdul Rahman
- InventorHasan Ahmed Rudayni
Keywords
Keywords
- pharmaceutical coating
- nanostarch
- avocado seed
- pumpkin peel
- capsule film
- plant excipient
- plasticizer
- drug delivery
Patent document and drawings
Patent document and drawings
The patent publication is mapped to this record. Patent drawings remain within that publication; no separately cleared public media package has been supplied.