US 12370288 B1Patent grantUnited States

Biobased Wound-Care Preparation

Official patent title

Biobased wound healing preparation and method of preparation thereof

Arabic title: مستحضر حيوي الأساس لالتئام الجروح وطريقة تحضيره

Invention

Problem

Wound dressings must manage adhesion, moisture, microbial risk, tissue compatibility, and healing while avoiding irritation and inconsistent composition. Natural-source mixtures also require rigorous control and biological validation.

Why it matters

A locally sourced, biobased preparation could create value from renewable plant and animal materials, but wound-care use requires strong evidence for sterility, safety, and healing performance.

Approach

The preparation combines an olive-leaf, beef-bone-meal, and moringa-seed-gel nanocomposite with selected organic ingredients, an adhesive component, and ZnO nanoparticles; the patent also describes acid hydrolysis and ZnO preparation steps.

Who may benefit

Potential beneficiaries include wound-dressing researchers, biomaterials developers, healthcare-product manufacturers, veterinary-care suppliers, and organizations valorizing agricultural or animal by-products.

Potential value

The disclosure integrates biobased structural components, optional antimicrobial or keratolytic ingredients, natural adhesives, and zinc-oxide nanoparticles in one preparation with specified particle size, pH, and composition ranges.

Background

Wound-care materials may protect tissue, retain moisture, reduce microbial contamination, and support repair. Biobased polymers and extracts offer renewable inputs, while zinc oxide and selected antimicrobial compounds may add functional activity. However, complex natural mixtures can vary by source and may introduce allergens, contaminants, or incompatible ingredients. Performance claims must therefore be tied to a defined wound model and compared with suitable controls. The disclosed formulation combines plant- and animal-derived components with an adhesive phase and zinc-oxide nanoparticles.

Technology overview

The preparation includes a nanocomposite of olive-leaf extract, beef bone meal, and moringa-seed gel; an organic fraction selected from beetroot dye, black cumin, sodium fusidate, salicylic acid, glycerin, and pomegranate pigment; an adhesive selected from several natural gels or cyanoacrylate; and 1–10 wt.% ZnO nanoparticles. The nanocomposite particles are claimed at 25 nm or less, with a formulation pH of 5–8. Manufacturing includes drying, acid hydrolysis, ZnO synthesis, and component blending.

Potential applications

Research on topical wound preparations.
Biobased dressing and adhesive development.
Veterinary wound-care formulation studies.
Valorization of plant and animal by-products.

Evidence-supported advantages

Uses multiple renewable or biobased inputs.
Combines structural, adhesive, and functional components.
Includes defined nanoparticle-size and pH ranges.
Provides a preparation route for the composite and ZnO.
Allows formulation choices among several organic and adhesive ingredients.

Development stage

A formulation and preparation method are described, with a claimed wound-healing time comparison; the supplied evidence does not establish a defined clinical study, human safety, sterility, or regulatory performance. The development stage was not independently verified.

Commercial opportunity

The concept may interest wound-dressing and veterinary-product developers. Advancement requires a fixed formulation, validated wound model, microbiology, cytotoxicity and sensitization testing, sterility and shelf life, source and allergen controls, impurity and residual-acid limits, comparison with standard care, scalable manufacture, and medical-device or drug regulatory assessment.

Patent classifications

WIPO IPC

A61L26/00Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
C08L1/02Compositions of macromolecular compounds
B82Y5/00Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures

CPC

A61L26/0052Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
C08L1/02Compositions of macromolecular compounds
A61L26/0004Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
A61K33/30Preparations for medical, dental or toiletry purposes
A61L26/0057Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
C08L3/02Compositions of macromolecular compounds
A61K31/60Preparations for medical, dental or toiletry purposes
A61K31/575Preparations for medical, dental or toiletry purposes
C08L33/06Compositions of macromolecular compounds
C08K2003/265Use of inorganic or non-macromolecular organic substances as compounding ingredients
C08K3/105Use of inorganic or non-macromolecular organic substances as compounding ingredients
A61K2300/00Preparations for medical, dental or toiletry purposes
A61L2300/30Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
B82Y5/00Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures
A61L2430/34Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles
A61L2400/12Sterilising materials or objects; disinfecting, sterilising or deodorising air; chemical aspects and materials of bandages, dressings, absorbent pads or surgical articles

Inventors

First inventorABM Sharif Hossain
InventorHasan Ahmed Rudayni
InventorMohammad Saad Aleissa
InventorLina Mohammed Ateeq Alneghery
InventorSulaiman Abdullah Ali Alsalameh
InventorMoniruddin Chowdhury
InventorFazliny Abdul Rahman

Keywords

wound healing
biobased preparation
olive leaf
moringa seed gel
beef bone meal
zinc oxide nanoparticles
bioadhesive
wound dressing

Patent document and drawings

The patent publication is mapped to this record. Patent drawings remain within that publication; no separately cleared public media package has been supplied.