Glauconite Nanorods for Cisplatin Delivery Studies
Official patent title
Cancer treatment method with nanocomposite
Arabic title: طريقة لعلاج السرطان باستخدام مركب نانوي
Invention
Invention
Problem
Cisplatin is effective against several tumors but can cause serious toxicity, while many carrier systems remain costly or insufficiently developed for controlled delivery.
Why it matters
A porous carrier that loads and releases cisplatin over time could support drug-delivery research aimed at controlling exposure, but biological safety must be demonstrated.
Approach
The disclosure exfoliates and rolls natural glauconite into porous aluminum silicate nanorods, loads cisplatin onto and within the nanorods, and contacts a cancerous sample with the resulting nanocomposite. It reports loading, release, and cell-viability characteristics under laboratory conditions.
Who may benefit
Potential beneficiaries include nanomedicine researchers, oncology drug-delivery groups, clay-mineral technologists, pharmaceutical formulation teams, and academic cancer laboratories.
Potential value
The technology combines an economical natural clay precursor, defined nanorod geometry and porosity, cisplatin-loading parameters, pH-dependent release, and laboratory cytotoxicity in one carrier platform.
Background
Background
Cisplatin is an established chemotherapy agent, but its use can be limited by toxicity, including nephrotoxicity. Drug-delivery carriers such as lipids, micelles, nanoparticles, and polymers are studied to manage exposure and adverse effects. Clay minerals provide layered structures, ion-exchange behavior, surface area, and adsorption capacity that may be useful for loading drugs. The publication focuses on glauconite, a naturally occurring aluminosilicate that had seen limited medical use, as a precursor for rolled porous nanorods carrying cisplatin.
Technology overview
Technology overview
Ground glauconite is dispersed in a water–dimethyl-sulfoxide mixture, washed with methanol, treated with cetyltrimethylammonium bromide, and extensively sonicated so exfoliated sheets roll into nanorods. The resulting porous structures have defined length, diameter, pore, and surface-area ranges and are mixed with cisplatin. The publication reports pH-dependent release periods and reduced viability of a contacted cancerous sample after 48 and 72 hours.
Potential applications
Potential applications
- Preclinical cisplatin-delivery research using porous clay-derived nanorods.
- Laboratory studies of pH-dependent loading and release from nanocarriers.
- Nanocomposite screening against cancerous cell samples in vitro.
- Materials research on value-added medical uses of natural glauconite.
Evidence-supported advantages
Evidence-supported advantages
- The carrier is produced from naturally occurring glauconite clay.
- The claims define nanorod dimensions, porosity, surface area, and cisplatin loading.
- Cisplatin release is reported over different periods at acidic and near-neutral pH.
- The publication reports reduced cancer-sample viability after specified contact periods.
Development stage
Development stage
Laboratory nanorod preparation, cisplatin loading and release, and cancer-sample testing are described; no animal or clinical validation was established, and the development stage was not independently verified beyond those reported studies.
Commercial opportunity
Commercial opportunity
The platform may support early research partnerships in nanomedicine and platinum-drug delivery. Translation would require shorter and scalable processing, mineral-purity controls, reproducible loading and release, normal-cell selectivity, biodistribution, pharmacokinetics, animal toxicology and efficacy, sterile manufacturing, and clinical evaluation. Cost and yield also require benchmarking.
Patent classifications
Patent classifications
WIPO IPC
- A61K47/69Preparations for medical, dental or toiletry purposes
- A61K33/243Preparations for medical, dental or toiletry purposes
- B82Y5/00Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures
CPC
- A61K47/02Preparations for medical, dental or toiletry purposes
- A61K9/0092Preparations for medical, dental or toiletry purposes
- A61K47/6923Preparations for medical, dental or toiletry purposes
- A61P35/00Specific therapeutic activity of chemical compounds or medicinal preparations
- A61K33/243Preparations for medical, dental or toiletry purposes
- A61K47/6929Preparations for medical, dental or toiletry purposes
- B82Y5/00Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures
Inventors
Inventors
- First inventorHassan A. Rudayni
- InventorAhmed Aly Allam
- InventorAya Fadlallah Abdelmonem Mohamed
- InventorMostafa R. Abukhadra
- InventorNohan Nasser Abdelfattah Ahmed
Keywords
Keywords
- aluminum silicate nanorods
- glauconite
- cisplatin
- drug delivery
- nanocomposite
- controlled release
- cancer cells
- porous carrier
Patent document and drawings
Patent document and drawings
The patent publication is mapped to this record. Patent drawings remain within that publication; no separately cleared public media package has been supplied.